Denali Therapeutics Inc chart

Last update: 2022-12-30
Key statistics and financials
Revenue per share 0.90
Dividend & YieldN/A$ (N/A)
Beta 1.45
Market capitalization 4.1B
Operating cash flow -237.55M
ESG Scores unknown

Company description

Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutic candidates for neurodegenerative diseases in the United States. It offers leucine-rich repeat kinase 2 (LRRK2) inhibitor product candidate, including BIIB122/DNL151, a small molecule inhibitor, which is in phase I and phase Ib clinical trials for the treatment of Parkinson's disease. The company also develops DNL310 that is in Phase I/II clinical trials for the treatment of hunter syndrome; DNL343, which is in phase 1 clinical trial the treatment of amyotrophic lateral sclerosis (ALS); AR443820/DNL788 completed a phase I clinical trial for the treatment of ALS, multiple sclerosis (MS), and Alzheimer's disease; and SAR443122/DNL758, which is in phase II clinical trial for the treatment of cutaneous lupus erythematosus. It has collaboration agreement with Takeda Pharmaceutical Company, Genentech, Inc., Sanofi, F-star Gamma Limited, F-star Biotechnologische Forschungs-Und Entwicklungsges M.B.H, F-star Biotechnology Limited, SIRION Biotech GmbH, Genzyme Corporation, Harvard University, the Michael J. Fox Foundation, and Centogene; and a research and option agreement with Secarna Pharmaceuticals GmbH & Co. KG. to develop antisense therapies in the field of neurodegenerative diseases. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.

Sector: Healthcare - Industry: Biotechnology

Financial data

Financial Statements

Cashflow Statement 2018-12-31 2019-12-31 2020-12-31 2021-12-31
Change To Liabilities 68.25M -5.25M 276.54M -11.96M
Total Cashflows From Investing Activities -287.42M 147.71M -623.21M -21.63M
Net Borrowings
Total Cash From Financing Activities 97.02M 6.19M 634.75M 19.35M
Change To Operating Activities -5.36M 8.18M 11.86M -8.46M
Issuance Of Stock 98.41M 6.19M 634.75M 19.35M
Net Income -36.24M -197.61M 71.14M -290.58M
Change In Cash -140.29M 2.33M 427.69M -213.67M
Effect Of Exchange Rate
Total Cash From Operating Activities 50.12M -151.58M 416.15M -211.39M
Depreciation 7.42M 7.99M 8.53M 8.59M
Change To Account Receivables
Other Cashflows From Financing Activities -1.39M
Change To Netincome 16.05M 35.12M 48.08M 91.01M
Capital Expenditures -3.39M -17.92M -3.1M -8.5M

Income Statement 2018-12-31 2019-12-31 2020-12-31 2021-12-31
Research Development 193.38M 193.38M
Income Before Tax -36.24M -197.97M 71.96M -291.16M
Net Income -36.24M -197.61M 71.14M -290.58M
Selling General Administrative 32.35M 46.48M 60.33M 79.06M
Gross Profit -14.02M -166.7M 123.04M -216.69M
Ebit -46.37M -213.18M 62.72M -295.75M
Operating Income -46.37M -213.18M 62.72M -295.75M
Interest Expense
Income Tax Expense -351k 823k -575k
Total Revenue 129.16M 26.68M 335.66M 48.66M
Cost Of Revenue 143.18M 193.38M 212.62M 265.35M
Total Other Income ExpenseNet 10.13M 15.22M 9.24M 4.59M
Net Income From Continuing Ops -36.24M -197.61M 71.14M -290.58M
Net Income Applicable To Common Shares -36.24M -197.61M 71.14M -290.58M

Balance Sheet Statement 2018-12-31 2019-12-31 2020-12-31 2021-12-31
Total Liabilities 115.14M 158.34M 453.75M 441.87M
Total Stockholder Equity 546.85M 394.89M 1.15B 962.29M
Other Current Liabilities 12.42M 18.74M 23.48M 320.3M
Total Assets 661.98M 553.23M 1.6B 1.4B
Common Stock 1.27M 1.29M 1.53M 1.55M
Other Current Assets 6.64M
Retained Earnings -227.94M -425.55M -354.42M -645M
Treasury Stock -649k 350k -245k -2.5M
Cash 77.12M 79.45M 507.14M 293.48M
Total Current Liabilities 32.79M 45.34M 71.7M 378.25M
Other Stockholder Equity -649k 350k -245k -2.5M
Property, Plant, and Equipment 25.16M 80.66M 73.46M 69.61M
Total Current Assets 480.84M 430.03M 1.5B 897.23M
Net Tangible Assets 546.85M 394.89M 1.15B 962.29M
Net Receivables 8.55M 5.67M 1.23M
Accounts Payable 1.89M 2.59M 1.07M 4.78M


Insider Transactions

Here are the insider transactions of stock shares related to Denali Therapeutics Inc:

Filer Name Transaction Text Ownership Date Filer Relation Shares
TESSIER LAVIGNE MARC TSale at price 30.48 per share.D2022-11-23Director20k
TESSIER LAVIGNE MARC TSale at price 30.20 - 30.33 per share.D2022-11-02Director20k
SCHUTH ALEXANDER OConversion of Exercise of derivative security at price 0.68 per share.I2022-10-07Chief Financial Officer20k
TESSIER LAVIGNE MARC TSale at price 30.74 - 31.08 per share.D2022-09-28Director20k
TESSIER LAVIGNE MARC TSale at price 31.61 - 32.43 per share.D2022-08-23Director20k
HO CAROLESale at price 31.98 per share.I2022-08-23Officer2.42k
KROGNES STEVE ESale at price 33.22 per share.D2022-08-19Director2.25k
SCHUTH ALEXANDER OSale at price 33.22 per share.I2022-08-19Chief Operating Officer2.58k
HO CAROLESale at price 33.22 per share.I2022-08-19Officer2.58k
WATTS RYAN JSale at price 33.22 per share.I2022-08-19Chief Executive Officer2.4k
SCHUTH ALEXANDER OStock Award(Grant) at price 0.00 per share.D2022-08-09Officer22.5k
HO CAROLEStock Award(Grant) at price 0.00 per share.D2022-08-09Officer22.5k
TESSIER LAVIGNE MARC TSale at price 35.60 - 36.15 per share.D2022-07-25Director20k
KROGNES STEVE EConversion of Exercise of derivative security at price 0.68 per share.D2022-07-19Director62.5k
FLATLEY JAY TStock Award(Grant) at price 0.00 per share.I2022-06-02Director5.99k
SATO VICKI LStock Award(Grant) at price 0.00 per share.D2022-06-02Director5.99k
COLE DOUGLAS GStock Award(Grant) at price 0.00 per share.D2022-06-02Director5.99k
TESSIER LAVIGNE MARC TStock Award(Grant) at price 0.00 per share.D2022-06-02Director5.99k
KLEIN PETER SStock Award(Grant) at price 0.00 per share.D2022-06-02Director5.99k
SCHENKEIN DAVID PStock Award(Grant) at price 0.00 per share.D2022-06-02Director5.99k
COOK JENNIFER EStock Award(Grant) at price 0.00 per share.D2022-06-02Director5.99k
THORNBERRY NANCYStock Award(Grant) at price 0.00 per share.D2022-06-02Director5.99k
TESSIER LAVIGNE MARC TSale at price 33.40 - 34.14 per share.D2022-03-23Director20k
TESSIER LAVIGNE MARC TSale at price 33.40 - 34.14 per share.D2022-03-23Director20k
KROGNES STEVE ESale at price 34.69 per share.D2022-02-11Chief Financial Officer2.56k
SCHUTH ALEXANDER OSale at price 34.68 per share.I2022-02-11Chief Operating Officer2.8k
HO CAROLESale at price 34.71 per share.I2022-02-11Officer2.92k
WATTS RYAN JSale at price 34.72 per share.I2022-02-11Chief Executive Officer9.49k
WATTS RYAN JConversion of Exercise of derivative security at price 5.28 - 9.60 per share.D2022-02-10Chief Executive Officer70.75k
KROGNES STEVE ESale at price 37.09 per share.D2022-02-09Chief Financial Officer1.3k
SCHUTH ALEXANDER OSale at price 37.10 per share.I2022-02-09Chief Operating Officer1.42k
HO CAROLESale at price 37.10 per share.I2022-02-09Officer1.42k
WATTS RYAN JSale at price 37.55 per share.I2022-02-09Chief Executive Officer2.72k
HARRIS ERIKStock Award(Grant) at price 0.00 per share.D2022-02-03Director6.87k
THORNBERRY NANCYStock Award(Grant) at price 0.00 per share.D2022-01-07Director627
KROGNES STEVE ESale at price 44.75 per share.D2022-01-05Chief Financial Officer2.23k
SCHUTH ALEXANDER OSale at price 44.77 per share.I2022-01-05Chief Operating Officer2.85k
HO CAROLESale at price 44.78 per share.I2022-01-05Officer2.85k
WATTS RYAN JSale at price 44.78 per share.I2022-01-05Chief Executive Officer5.01k
KROGNES STEVE EStock Award(Grant) at price 0.00 per share.D2022-01-03Chief Financial Officer31k
SCHUTH ALEXANDER OStock Award(Grant) at price 0.00 per share.D2022-01-03Chief Operating Officer31k
HO CAROLEStock Award(Grant) at price 0.00 per share.D2022-01-03Officer31k
WATTS RYAN JStock Award(Grant) at price 0.00 per share.D2022-01-03Chief Executive Officer62k
TESSIER LAVIGNE MARC TSale at price 43.87 - 45.72 per share.I2021-12-30Director63.13k
TESSIER LAVIGNE MARC TStock Gift at price 0.00 per share.D2021-12-13Director200k
SCHUTH ALEXANDER OSale at price 41.82 - 42.45 per share.I2021-12-06Chief Operating Officer10k
HO CAROLESale at price 42.52 per share.D2021-12-06Officer1.48k
WATTS RYAN JSale at price 44.39 - 46.35 per share.I2021-12-01Chief Executive Officer18.33k
SATO VICKI LSale at price 52.49 - 53.30 per share.D2021-11-10Director1.67k
SCHUTH ALEXANDER OSale at price 52.65 - 53.23 per share.I2021-11-04Chief Operating Officer10k
SATO VICKI LSale at price 50.05 per share.D2021-11-01Director1.67k

Insider transaction explanations

Insider buying is the legal purchase of shares by a senior executive or director of a company. "Filer Name" corresponds to the name of the stock buyer or seller. "Transaction Text" describes the transaction. "Ownership" gives information about the transaction type. "Date" is the reported transaction date. "Filer Relation" gives the role of the insider in the company. "Shares" is the value of the transaction. You will find the complete description of the General Transaction Codes on the SEC dedicated page


Investment strategy backtesting

These are the result of three automatic investment systems applied to Denali Therapeutics Inc. You will find the performance of an systematic investment system, a momentum strategy, and a buy the dip trading strategy.


Systematic investment results on Denali Therapeutics Inc

Here is the result of two systematic investment strategies applied to Denali Therapeutics Inc. The first strategy automatically buys the first day of the month, and the second strategy buys the fifteenth day of the month.

Systematic investment equity curve on Denali Therapeutics Inc

The following chart shows the equity curve of the two systematic investment strategies applied to Denali Therapeutics Inc:

Denali Therapeutics Inc automated entries

The systematic investment strategy that buys the first day of the month would give a performance of 132.92% on the backtest period.

Performance at glance

Performance

132.92 %

Latent gain

2637.41 $

Invested capital

1984.27 $

Annualized return

32.58 %
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Momentum strategy results on Denali Therapeutics Inc

This is the result of two momentum investment strategies applied to Denali Therapeutics Inc. The first strategy uses a momentum signal calculated on one quarter, and the second uses a momentum signal calculated on two quarters.

Momentum entry openings on Denali Therapeutics Inc

The following chart shows all the entries opened by the momentum investment system on Denali Therapeutics Inc:

Denali Therapeutics Inc momentum entries
  • The first momentum investment strategy would give 148.71% of return on Denali Therapeutics Inc. That represents 7500.79$ of latent gain with 5043.77$ of employed capital.
  • The second momentum investment strategy would give 194.41% of return on Denali Therapeutics Inc. That represents 5377.12$ of latent gain with 2765.84$ of employed capital.
Performance at glance (1Q Momentum)

Performance

148.71 %

Latent gain

7500.79 $

Invested capital

5043.77 $

Annualized return

1.0 %
Performance at glance (2Q Momentum)

Performance

194.41 %

Latent gain

5377.12 $

Invested capital

2765.84 $

Annualized return

54.0 %

Momentum equity curve on Denali Therapeutics Inc

The following chart shows the equity curve of the two momentum strategies applied to Denali Therapeutics Inc:

Denali Therapeutics Inc momentum equity

Note: the dividends potentially given by Denali Therapeutics Inc are not integrated into the calculation of the equity curve neither the performance of the strategy. The integration of the dividends will be available soon.


Employed capital on Denali Therapeutics Inc

The following chart shows the employed capital evolution of the two momentum strategies on Denali Therapeutics Inc since the beginning:

Denali Therapeutics Inc

Note: the algorithm buys for a maximum of 250$ per entry. If the stock price is greater than 250$, the system buys only one stock per entry. The investment system stops automatically when the financial exposure reaches 10000$.


Buy the dip strategy result on Denali Therapeutics Inc

Buy the dip entry openings on Denali Therapeutics Inc

Denali Therapeutics Inc

The performance achieved by the robo-advisor on Denali Therapeutics Inc is 2.08%. That represents 5.6$ of latent gain with 269.5$ of employed capital. The following chart shows Denali Therapeutics Inc stock price with all the entries opened by the automated investment system.

Note: The blue line represents the weekly stock price of Denali Therapeutics Inc, and the green triangles represent the entry openings. The artificall robo-advisor needs at least 100 weeks of trading history to work.

Performance at glance

Performance

2.08 %

Latent gain

5.6 $

Invested capital

269.5 $

Annualized return

1.0 %

Equity curve of the strategy applied to Denali Therapeutics Inc

The following chart shows the result of the investment strategy applied to Denali Therapeutics Inc:

Denali Therapeutics Inc

Note: the dividends potentially given by Denali Therapeutics Inc are not integrated into the calculation of the equity curve neither the performance of the strategy. The integration of the dividends will be available soon.


Employed capital on Denali Therapeutics Inc

The following chart shows the employed capital evolution since the beginning of the investment strategy on Denali Therapeutics Inc:

Denali Therapeutics Inc

Note: the algorithm buys for a maximum of 250$ per entry. If the stock price is greater than 250$, the system buys only one stock per entry. The investment system stops automatically when the financial exposure reaches 10000$.


Investment strategies comparison on Denali Therapeutics Inc

In this section, I will compare the three previous investment strategies applied to Denali Therapeutics Inc.

Equity curve comparison on Denali Therapeutics Inc

The following chart shows the equity curve of the artificall advisor, the trend folowing and the automatic investment strategies:

Denali Therapeutics Inc investment strategy comparison

Employed capital comparison on Denali Therapeutics Inc

Denali Therapeutics Inc investment comparison

Performance comparison on Denali Therapeutics Inc

Strategy Latent Profit Growth Employed capital CAGR
Automatic investment 132.92% 2637.41$ 1984.27$ 32.58%
Momentum 1 quarter 148.71% 7500.79$ 5043.77$ 38.73%
Momentum 2 quarters 194.41% 5377.12$ 2765.84$ 54.0%
Non-directional 2.08% 5.6$ 269.5$ 1.0%
Annualized return comparison

Automatic investment

32.58 %

Momentum 1Q

54.0 %

Momentum 2Q

54.0 %

Non-directional

1.0 %

Correlated stocks

Here are the most positively and negatively correlated stocks with Denali Therapeutics Inc:

Positive correlations

Most correlated stocks this year

  • Denali Therapeutics Inc

  • Most correlated stocks last 3 months

  • Denali Therapeutics Inc
  • KWOON CHUNG BUS

  • Negative correlation

    Most negatively correlated stocks this year


    Most negatively correlated stocks last 3 months

  • PSBC

  • Note: The algorithm computes the probability of correlation between Denali Therapeutics Inc and the other stocks. There may be false positives or some missing correlated stocks. If the price of Denali Therapeutics Inc does not vary for 36 weeks, the correlation calculation result will be wrong.


    Company information

    Company name Denali Therapeutics Inc
    Country United States
    City South San Francisco
    Address 161 Oyster Point Boulevard
    Phone 650 866 8548
    Website www.denalitherapeutics.com
    FullTime employees 413
    Industry Biotechnology
    Sector Healthcare
    Exchange XNAS
    Ticker DNLI
    Market www.nasdaq.com

    Denali Therapeutics Inc ESG Scores

    Environment scores

    Environment ESG Factors Scores
    Environment Score 0
    Peer Environment Performance unknown
    Environment Percentile unknown
    Palm Oil unknown
    Nuclear unknown
    Fur Leather unknown
    GMO unknown
    Coal unknown
    Pesticides unknown
    Animal Testing unknown

    Social scores

    Social ESG Factors Scores
    Social Score 0
    Peer Social Performance unknown
    Social Percentile unknown
    Highest Controversy unknown
    Peer Highest Controversy Performance unknown
    Adult unknown
    Gambling unknown
    Alcoholic unknown
    Tobacco unknown
    Catholic unknown
    Controversial Weapons unknown
    Small Arms unknown
    Military Contract unknown
    Peer Count unknown

    Related Controversy:


    Governance scores

    Governance ESG Factors Scores
    Governance Score 0
    Peer Governance Performance unknown
    Governance Percentile unknown

    ESG at glance
    Total ESG Scores: unknown
    Environment Score: 0
    Social Score: 0
    Governance Score: 0

    ESG Performance: unknown

    Peer Group: unknown

    Peer Esg Score Performance: unknown

    Rating Year: unknown

    Rating Month: unknown

    Max Age: unknown

    Percentile: unknown